The psychedelic, DOI, increases dopamine release in nucleus accumbens to predictable rewards and reward cues
bioRxiv (Cold Spring Harbor Laboratory) March 31, 2024 David Martin, Á.v. Delgado, Donna J. Calu preprint
Abstract Psychedelics produce lasting therapeutic responses in neuropsychiatric diseases suggesting they may disrupt entrenched associations and catalyze learning. Here, we examine psychedelic effects on dopamine signaling in the nucleus accumbens (NAc) core, a region extensively linked to reward learning, motivation, and drug-seeking. We measure phasic dopamine transients following acute...