Effects of psychedelic, DOI, on nucleus accumbens dopamine signaling to predictable rewards and cues in rats
Neuropsychopharmacology July 6, 2024 David Martin, Angel M. Delgado, Donna J. Calu 3 citations
Psychedelics produce lasting therapeutic responses in neuropsychiatric diseases suggesting they may disrupt entrenched associations and catalyze learning. Here, we examine psychedelic 5-HT2A/2C agonist, DOI, effects on dopamine signaling in the nucleus accumbens (NAc) core, a region extensively linked to reward learning, motivation, and drug-seeking. We measure phasic dopamine transients...