Self-modelling, theory of mind, and free will are three manifestations of a single substrate-mechanical mechanism: forward-modelling under bounded race-architecture. The substrate simulates hypothetical states and weights current decision-races by simulated outcomes. Self-modelling is the data-structure forward-modelling requires; theory of mind is forward-modelling applied recursively to another forward-modeller; free will is forward-modelling's translation of future friction into present friction-gradient. The framework's central thesis: we are free within our context, not free from our context. A dissolutionist response addresses the libertarian-versus-deterministic free-will polarity and the zombie argument, identifying an instantiation-family sharing a structural requirement of friction-free instantiation.
A framework is only useful if it can be proven wrong in a measurable way. This paper turns the compound-race-pathology framework into five concrete trial designs that others can run, refine, or disprove, each specifying in advance what would count as failure. The protocols cover treatment-resistant depression using ketamine plus CBT consolidation or psilocybin with substrate-vector-matched integration, a long COVID multi-target factorial trial, a multi-axis biomarker profiling approach for depression, and CAR-T plus tolerance-stabilization for autoimmune disease. Each trial design includes substrate-vector entry criteria, 4D stratification analysis, and framework-pivotal R-condition specifications. The author, an independent researcher without clinical credentials, explicitly invites domain-expert collaboration and notes that specific intervention development requires standard clinical methodology.