Neuroscience and Biobehavioral Reviews
June 1, 2026
Agustin Ibanez, Nick Roth, Aaron Colverson et al.
Metaphors have long played multiple roles in conceptualizing the mind and brain, guiding the development and refinement of theoretical models and empirical questions. Early analogies (comparing the brain to hydraulic systems, telephone exchanges, factories, or libraries) offered shortcuts to understanding aspects of cognition, memory, and brain dynamics. From theoretical frameworks, metaphors...
medRxiv
February 7, 2025
Andrew G. Breithaupt, Georges Naasan, Suzanne M. Shdo et al.
preprint
Abstract Psychosis is a common symptom in neurodegenerative diseases that contributes to significant patient and caregiver burden. While neuroimaging studies have implicated various brain regions in psychosis, findings have been inconsistent across different disease entities and psychosis subtypes. This study aimed to identify structural neuroanatomic changes associated with specific patterns...
Brain
April 9, 2013
Winston Chiong, Stephen M. Wilson, Mark D’Esposito et al.
234 citations
Large-scale brain networks are integral to the coordination of human behaviour, and their anatomy provides insights into the clinical presentation and progression of neurodegenerative illnesses such as Alzheimer's disease, which targets the default mode network, and behavioural variant frontotemporal dementia, which targets a more anterior salience network. Although the default mode network is...
Cerebral Cortex
March 7, 2011
Elizabeth C. Mormino, Andre Smiljic, Amynta O. Hayenga et al.
349 citations
Although beta-amyloid (Aβ) deposition is a characteristic feature of Alzheimer's disease (AD), this pathology is commonly found in elderly normal controls (NC). The pattern of Aβ deposition as detected with Pittsburgh compound-B positron emission tomography (PIB-PET) imaging shows substantial spatial overlap with the default mode network (DMN), a group of brain regions that typically...