Use and efficacy of low-dose ketamine in the management of acute postoperative pain: a review of current techniques and outcomes
Pain August 1, 1999 Roger Schmid, Alan N. Sandler, Joel Katz 547 citations
Ketamine hydrochloride is a well known general anesthetic and short acting analgesic in use for almost 3 decades. The role of the NMDA receptor in the processing of nociceptive input has led naturally to renewed clinical interest in N-methyl-D-aspartate (NMDA) receptor antagonists such as ketamine. This paper reviews the use and efficacy of low-dose ketamine in the management of acute...