Comparative and Interactive Human Psychopharmacologic Effects of Ketamine and Amphetamine
Archives of General Psychiatry September 1, 2005 John H. Krystal, Edward Perry, Ralitza Gueorguieva et al. 323 citations
BACKGROUND: In healthy individuals, ketamine hydrochloride and amphetamine sulfate produce cognitive, behavioral, and subjective effects resembling endogenous psychoses. Studying the comparative and interactive effects of these agents may provide insights into the roles of the glutamate and monoamine systems in psychosis and cognition. OBJECTIVES: To directly compare the effects of ketamine and...