Antagonism of histamine-activated adenylate cyclase in brain by D-lysergic acid diethylamide.
Proceedings of the National Academy of Sciences December 1, 1977 J P Green, C L Johnson, Harel Weinstein et al. 91 citations
D-Lysergic acid diethylamide and D-2-bromolysergic acid diethylamide are competitive antagonists of the histamine activation of adenylate cyclase [ATP pyrophosphate-lyase (cyclizing); E.C. 4.6.1.1] in broken cell preparations of the hippocampus and cortex of guinea pig brain. The adenylate cyclase is linked to the histamine H2-receptor. Both D-lysergic acid diethylamide and D-2-bromolysergic...