Ketamine pharmacotherapy for major depressive disorder: A narrative review
Progress in Neuro-Psychopharmacology and Biological Psychiatry February 27, 2026 Chris H. Miller, Angela Hickman, Caitlin Baten et al. 2 citations
Ketamine pharmacotherapy provides a novel treatment option for major depressive disorder (MDD) and has generated a large, growing body of research regarding its biochemical and clinical properties. This narrative review summarizes the history of ketamine's development, beginning as a general anesthetic, continuing with a discovery of its antidepressant properties, and leading up to its landmark...
DOI: 10.1016/j.pnpbp.2026.111651 (opens in new tab)
Major depressive disorder
Ketamine
Antidepressant
Pharmacotherapy
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