Synthesis and Characterization of 5-MeO-DMT Succinate for Clinical Use
ACS Omega December 2, 2020 Alexander M. Sherwood, Romain Claveau, Rafael Lancelotta et al. 38 citations
To support clinical use, a multigram-scale process has been developed to provide 5-MeO-DMT, a psychedelic natural product found in the parotid gland secretions of the toad, Incilius alvarius. Several synthetic routes were initially explored, and the selected process featured an optimized Fischer indole reaction to 5-MeO-DMT freebase in high-yield, from which the 1:1 succinate salt was produced...