Prolonged epigenetic and synaptic plasticity alterations following single exposure to a psychedelic in mice
bioRxiv (Cold Spring Harbor Laboratory) February 25, 2021 Mario de la Fuente Revenga, Bohan Zhu, Christopher A. Guevara et al. 11 citations preprint
Clinical evidence suggests a potential therapeutic effect of classic psychedelics for the treatment of depression. The most outstanding and distinct characteristic is the rapid and sustained antidepressant action with one single exposure to the drug. However, the biological substrates and key mediators of psychedelics’ enduring action remain unknown. Here, we show that a single administration...