Summary This article highlights the relevance of the humanities to psychiatric discussions. It considers Thomas De Quincey’s autobiographical Confessions of an English Opium-Eater (1821), where the author charts his opium experiences and dependence. The text provides an intersection of subjective and objective evaluations of drug use, and records experiences undertaken before establishment of...
BACKGROUND: The intravenous administration of ketamine, an N-methyl-D-aspartate receptor antagonist, results in a great improvement of depression symptoms, but it is not clear for how long. This single-case trial was conducted to explore the duration of improvement and the effects of a second administration on the clinical outcome. METHODS: In an open label trial, a 55-year-old male patient...
BACKGROUND: Recently, reports from North America have indicated that the intravenous infusion of ketamine hydrochloride (an N-methyl-d-aspartate receptor antagonist) results in a sudden and robust improvement of depression symptoms. OBJECTIVE: To corroborate antidepressant effectiveness of IV ketamine in a patient with a co-occurring substance use disorder for the first time in a European...