In this study, we provide the first study to integrate molecular and functional neuroimaging during psychedelic drug effects in humans. Using simultaneous PET-MRI technology, we describe multiple brain actions of lysergic acid diethylamide (LSD) in healthy volunteers. We quantify the occupancy of LSD at cerebral serotonin 2A receptors and show that LSD increases global cerebral blood flow and...
Electroconvulsive therapy (ECT) is often the last resort in medically treatment-resistant patients. The mechanisms of its efficacy are still somewhat poorly understood. However, it is clearly a highly effective treatment for severe and psychotic depression, as well as other severe neuropsychiatric conditions [[1]Weiner R.D. Reti I.M. Key updates in the clinical application of electroconvulsive...