Psilocybin-enhanced fear extinction linked to bidirectional modulation of cortical ensembles.
Nature Neuroscience June 1, 2025 Sophie A. Rogers, Elizabeth A. Heller, Gregory Corder 11 citations
The psychedelic drug psilocybin demonstrates rapid and long-lasting efficacy across neuropsychiatric disorders that are characterized by behavioral inflexibility. However, its impact on the neural activity underlying sustained changes in behavioral flexibility has not been characterized. To test whether psilocybin enhances behavioral flexibility by altering activity in cortical neural...
DOI: 10.1038/s41593-025-01964-9 (opens in new tab)
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Psychedelics
Fear-response
Brain-plasticity
Behavioral-science