Inhibition of cortico-amygdala projections underlies affective bias modification by psilocybin
bioRxiv (Cold Spring Harbor Laboratory) March 4, 2026 Matthew D. B. Claydon, Justyna K. Hinchcliffe, Julia M. Bartlett et al.
Abstract Psilocybin, a serotonergic psychedelic, can produce rapid and enduring antidepressant effects in patients with major depressive disorder (MDD)[1, 2], yet the neural mechanisms underlying these effects remain unclear. Negative affective biases are an important neuropsychological mechanism central to the development and perpetuation of MDD[3]. Using a translational rodent model, we...