Bortolotto Za

Inhibition of cortico-amygdala projections underlies affective bias modification by psilocybin

bioRxiv (Cold Spring Harbor Laboratory) March 4, 2026 Matthew D. B. Claydon, Justyna K. Hinchcliffe, Julia M. Bartlett et al. preprint

Abstract Psilocybin, a serotonergic psychedelic, can produce rapid and enduring antidepressant effects in patients with major depressive disorder (MDD)[1, 2], yet the neural mechanisms underlying these effects remain unclear. Negative affective biases are an important neuropsychological mechanism central to the development and perpetuation of MDD[3]. Using a translational rodent model, we...