Preprints.org
September 3, 2026
Izak Tait, Ziqi Wang, Joshua Bensemann
preprint
This paper explores the classification of artificial consciousness through the lens of the Building Blocks Theory, an attributional functionalist framework. Previous research indicates that while current transformer-based Large Language Models (LLMs) satisfy seven of the nine functional prerequisites for phenomenal consciousness, they fundamentally lack recurrent computing and processing, as...
Communications Biology
February 26, 2026
Tianjie Li, Erin. E. Reynolds, Ziqi Wang et al.
PcncAAAD is a noncanonical fungal aromatic L-amino acid decarboxylase (AAAD) featuring a unique appendage C-terminal domain (CTD) and two metal-binding sites. Unlike its mammalian and plant counterparts, PcncAAAD is activated by calcium, although the exact activation mechanism remains unclear. Here, we establish an in silico RMSD-based evaluation model through molecular dynamics simulations,...
Research Square
April 28, 2025
Yi Wang, Tianjie Li, Erin S. Reynolds et al.
Abstract PcncAAAD is a calcium-activatable noncanonical aromatic L-amino acid decarboxylase (AAAD) featuring a unique appendage C-terminal domain (CTD) and two metal-binding sites. In this study, we establish an in silico RMSD-based evaluation model through molecular dynamics simulations, validated by in vitro enzyme assays, to decipher the enzyme’s calcium activation mechanism. Between the two...
Journal of Artificial Intelligence and Consciousness
December 1, 2022
Izak Tait, Ziqi Wang, Tahua O’Leary et al.
The established theories and frameworks on consciousness in the academic literature as related to artificial intelligence (AI), are rooted in anthropocentricism. Even those theories created intentionally for AI are based on the levels of consciousness as it is understood in humans primarily, and in other animals secondarily. This paper will discuss why such anthropocentric frameworks are built...