Inhibition of NMDA receptors and other ion channel types by membrane-associated drugs.
Frontiers in Pharmacology 2025 Elizabeth G Neureiter, M Quincy Erickson-Oberg, Aparna Nigam et al. 4 citations
N-methyl-D-aspartate receptors (NMDARs) are ligand-gated ion channels present at most excitatory synapses in the brain that play essential roles in cognitive functions including learning and memory consolidation. However, NMDAR dysregulation is implicated in many nervous system disorders. Diseases that involve pathological hyperactivity of NMDARs can be treated clinically through inhibition by...