John W. Newcomer

NMDA receptor regulation of memory and behavior in humans

Hippocampus October 1, 2001 John W. Newcomer, John H. Krystal 238 citations

N-methyl-D-aspartate (NMDA) receptor hypofunction is associated with a range of effects on cognition and behavior in whole animal and human studies. NMDA receptor hypofunction within the brain, which can be induced experimentally in vivo using NMDA receptor antagonist drugs, produces adverse effects on memory function. The results suggest that NMDA receptor hypofunction can preferentially...