Molecular design of the N-methyl-D-aspartate receptor binding site for phencyclidine and dizolcipine.
Proceedings of the National Academy of Sciences of the United States of America August 15, 1995 A V Ferrer-Montiel, W Sun, M Montal
The N-methyl-D-aspartate receptor (NMDAR), a pivotal entity for synaptic plasticity and excitotoxicity in the brain, is a target of psychotomimetic drugs such as phencyclidine (PCP) and dizolcipine (MK-801). In contrast, a related glutamate receptor, the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate/kainate receptor GluR1, is weakly sensitive to these drugs. Three point mutations on...