HippocampusOctober 7, 2025Yiru Dong, Jundi Wang, Olivia Ge et al.
Anorexia nervosa (AN) has high mortality and relapse rates, yet no accepted pharmacotherapies. Reports based on six individuals suggest that ketogenic diet (KGD) combined with sub‐anesthetic ketamine (KET) is an effective treatment. The animal model, Activity‐Based Anorexia (ABA), captures AN's maladaptive behaviors of voluntary food restriction, excessive exercise, severe weight loss,...
Physiology & BehaviorSeptember 1, 2025Yiru Dong, Sebastian Goodwin-Groen, Jessie Ma et al.4 citations
The activity-based anorexia (ABA) animal model captures key maladaptive behaviors of anorexia nervosa - starvation-evoked hyperactivity, voluntary food restriction, severe weight loss and elevated anxiety-like behavior. By repeating ABA induction, the model reveals an animal's gain of resilience against ABA relapses and concomitant synaptic plasticity. We review findings on the efficacy of...
Anorexia nervosa (AN) is an eating disorder with the second highest mortality of all mental illnesses and high relapse rate, especially among adult females, yet with no accepted pharmacotherapy. A small number of studies have reported that adult females who struggled with severe and relapsing AN experienced sustained remission of the illness following ketamine infusions. Two other reports...