SUMMARY The evolution of a spiking focus induced by topical application of mescaline, as well as the concomitant alterations in the free amino acids in the two ectosylvian and the two marginal areas, were studied in cats pretreated with nonconvulsant doses of pentetrazol or caffeine. The spiking focus appeared earlier than it did in noninjected animals; the spikes were very frequent and...
SUMMARY An cctosylvian spiking focus, induced by topical application of mescaline, brought about changes in nitrogenous compounds not only in the focus but throughout the cerebral cortex. Prior to the onset of the spiking focus, 2 min after mescaline application, ammonia levels increased significantly in all neocortical areas, especially at the focus and homolateral marginal gyrus; free amide...