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T. Sargent

2 papers in the library · 33 citations · publishing 1971-1973

Papers

Animal Pharmacology and Human Psychopharmacology of 3-Methoxy-4,5-Methylenedioxyphenylisopropylamine (MMDA)

Pharmacology January 1, 1973 Alexander T. Shulgin, T. Sargent, Carolina Lopez Naranjo 33 citations

The compound 3-methoxy-4,5-methylenedioxyphenyl isopropylamine (MMDA) was synthesized and tested for psychodysleptic effects. In animals, its pharmacology was generally unremarkable except for a hypotensive effect in dogs, and the therapeutic index (LD50 rat/MED50 human) was 85. In humans, MMDA enhanced feeling and eyes-closed visual imagery without causing hallucinations or disturbing the sensorium. Reality testing and environmental contact remained intact, though a tendency to withdraw into drowsiness or fantasy occurred. The state of increased emotional availability was easily manipulated in psychotherapy and appeared to enhance insight into subconscious content.

DOI: 10.1159/000136416 (opens in new tab) Psychopharmacology Euphoriant Psychology Neuroscience

4-Bromo-2,5-dimethoxyphenylisopropylamine, a new centrally active amphetamine analog.

Pharmacology January 1, 1971 A. Shulgin, T. Sargent, C. Naranjo

A new centrally active halo-amine, 4-bromo-2,5-dimethoxyphenylisopropylamine, enhanced emotional and intellectual perception in clinical evaluation without producing the imagery and perceptual distortions typical of related psychotomimetics. The authors suggest these properties could make the compound valuable as an adjunct to psychotherapy.

DOI: 10.1159/000136181 (opens in new tab) Full text (opens in new tab) Chemistry Medicine Psychology