Repeated small doses of MDMA produce a lasting pro-convulsant effect that lowers the threshold for limbic seizures and increases metabolic hyperexcitability in mice, even before structural changes like mossy fiber sprouting appear. While clinical seizures after MDMA use are often attributed to acute effects such as hyponatremia and hyperthermia, additional mechanisms involving monoaminergic systems may also contribute. Chronic effects of MDMA on seizure threshold have been underexplored, and this review presents preliminary data showing that seizure susceptibility emerges early, without accompanying mossy fiber sprouting.
Patients with complex partial seizures (CPSs) recall dreams about twice as often as patients with generalized seizures, regardless of which side of the temporal lobe the epileptic focus is on, the presence of a visible brain lesion, or whether a seizure occurred the previous day. Nearly all medicated epilepsy patients in the study could recall dreams, but CPS patients showed a significantly higher dream recall frequency than reported in earlier work. The finding supports the idea that temporoparietal areas of both hemispheres contribute to dream production and recall.