Response dynamics of midbrain dopamine neurons and serotonin neurons to heroin, nicotine, cocaine, and MDMA
Cell Discovery October 5, 2018 Chao Wei, Xiao Han, Danwei Weng et al. 83 citations
Abstract Heroin, nicotine, cocaine, and MDMA are abused by billions of people. They are believed to target midbrain dopamine neurons and/or serotonin neurons, but their effects on the dynamic neuronal activity remain unclear in behaving states. By combining cell-type-specific fiber photometry of Ca 2+ signals and intravenous drug infusion, here we show that these four drugs of abuse profoundly...