Ascorbic acid prevents 3,4-methylenedioxymethamphetamine (MDMA)-induced hydroxyl radical formation and the behavioral and neurochemical consequences of the depletion of brain 5-HT
Synapse 2001 Mahalakshmi Shankaran, Bryan K. Yamamoto, Gary A. Gudelsky 97 citations
MDMA-induced 5-HT neurotoxicity has been proposed to involve oxidative stress due to increased formation of hydroxyl radicals. Recently, MDMA-induced 5-HT neurotoxicity has been shown to be accompanied by a suppression of behavioral and neurochemical responses to a subsequent injection of MDMA. The intent of the present study was to examine whether suppression of the MDMA-induced formation of...
DOI: 10.1002/1098-2396(200104)40:1<55::aid-syn1026>3.0.co;2-o (opens in new tab)
MDMA
Ascorbic acid
Neurochemical
Neurotoxicity
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