Abstract The current study aimed to elucidate the role of pharmacokinetic ( PK ) parameters and neurotransmitter efflux in explaining variability in (±) 3, 4‐methylenedioxymethamphetamine ( MDMA ) self‐administration in rats. PK profiles of MDMA and its major metabolites were determined after the administration of 1.0 mg/kg MDMA (iv) prior to, and following, the acquisition of MDMA...
It has been suggested that the response to novelty and impulsivity predict the latency to acquisition and maintenance of drug self-administration, respectively. The aim of this study was to examine the relationship between these two traits and (1) the latency to acquisition and (2) maintenance (drug-seeking) of 3,4-methylenedioxymethamphetamine (MDMA) self -administration. Impulsivity, measured...
The present study provides a profile of acqui- sition and maintenance of self-administration of +/-3,4- methylenedioxymethamphetamine (MDMA) obtained from a large cohort of rats tested during a 2 year period. Of the 128 rats, 49% self-administered 1.0 mg/kg/infusion MDMA to an initial criterion within a 25 day cut-off period. The number of test sessions required to meet this initial criterion...