Acquisition of MDMA self‐administration: pharmacokinetic factors and MDMA‐induced serotonin release
Addiction Biology June 14, 2013 Sarah Bradbury, Judith Bird, Joyce Colussi‐mas et al. 59 citations
Abstract The current study aimed to elucidate the role of pharmacokinetic ( PK ) parameters and neurotransmitter efflux in explaining variability in (±) 3, 4‐methylenedioxymethamphetamine ( MDMA ) self‐administration in rats. PK profiles of MDMA and its major metabolites were determined after the administration of 1.0 mg/kg MDMA (iv) prior to, and following, the acquisition of MDMA...