Dantrolene sodium fails to reverse robust brain hyperthermia induced by MDMA and methamphetamine in rats.
Psychopharmacology April 1, 2023 Keaton T Cameron-Burr, R Aaron Bola, Eugene A. Kiyatkin 5 citations
Hyperthermia induced by psychomotor stimulants may cause leakage of the blood-brain barrier, vasogenic edema, and lethality in extreme cases. Current treatments such as whole-body cooling are only symptomatic and a clear need to develop pharmacological interventions exists. Dantrolene sodium, a peripheral muscle relaxant used in the treatment of malignant hyperthermia, has been proposed as...