Brain hyperthermia induced by MDMA (‘ecstasy’): modulation by environmental conditions
European Journal of Neuroscience July 1, 2004 Paul Brown, Eugene A. Kiyatkin 105 citations
Abstract Drugs of abuse, such as 3,4‐methylenedioxymethamphetamine (MDMA), often have more powerful effects during states of increased activation and under specific environmental conditions. Because hyperthermia is a major complication of MDMA use and a factor potentiating neurotoxicity, we examined the effects of this drug (9 mg/kg, sc; approximately one‐fifth of the known LD 50 in rats) on...