Diverse Psychotomimetics Act Through a Common Signaling Pathway
Science November 21, 2003 Per Svenningsson, Eleni T. Tzavara, Robert Carruthers et al. 312 citations
Three distinct classes of drugs: dopaminergic agonists (such as D-amphetamine), serotonergic agonists (such as LSD), and glutamatergic antagonists (such as PCP) all induce psychotomimetic states in experimental animals that closely resemble schizophrenia symptoms in humans. Here we implicate a common signaling pathway in mediating these effects. In this pathway, dopamine- and an adenosine...