Open-label study of consecutive ibogaine and 5-MeO-DMT assisted-therapy for trauma-exposed male Special Operations Forces Veterans: prospective data from a clinical program in Mexico.
The American Journal of Drug and Alcohol Abuse September 3, 2023 Alan Kooi Davis, Yitong Xin, Nathan D. Sepeda et al. 29 citations
Combined ibogaine and 5-MeO-DMT assisted therapy produced rapid and large improvements in mental health among trauma-exposed Special Operations Forces Veterans. In a sample of 86 male veterans, self-reported PTSD symptoms, depression, anxiety, insomnia severity, and post-concussive symptoms all significantly decreased from baseline to one-month follow-up. Satisfaction with life, psychological flexibility, and cognitive functioning also significantly improved. The therapeutic effects appeared durable up to six months. The study was a prospective clinical program evaluation conducted in Mexico, and the authors call for future controlled research to confirm these findings.