Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance
Psychopharmacology July 7, 2006 Roland R. Griffiths, William A. Richards, U. Mccann et al. 1,684 citations
A high dose of psilocybin, given under supportive conditions to hallucinogen-naïve adults who regularly participate in religious or spiritual activities, produced acute perceptual changes, subjective experiences, and labile moods including anxiety. It also increased measures of mystical experience. Two months later, volunteers rated the psilocybin experience as having substantial personal meaning and spiritual significance and attributed sustained positive changes in attitudes and behavior to it, consistent with ratings by community observers. The ability to prospectively occasion such experiences allows rigorous scientific investigation of their causes and consequences.