Delphine Allorge - The Consciousness Library

The potential of keratinized matrices for the retrospective exploration of repeated ayahuasca use by patients

Clinical Toxicology November 2, 2023 Alexandr Gish, Florian Hakim, Camille Richeval et al. 4 citations

Dear Editor,Ayahuasca is a traditional psychoactive infusion of the Amazonian indigenous people composed mainly of a mixture of Psychoteria viridis or related species (containing N,N-dimethyltrypta...

DOI: 10.1080/15563650.2023.2282943 Ayahuasca Retrospective cohort study

Metabolite elucidation of 2-fluoro-deschloroketamine (2F-DCK) using molecular networking across three complementary in vitro and in vivo models.

Drug Testing and Analysis 2022 Thomas Gicquel, Romain Pelletier, Camille Richeval et al. 32 citations

This work first aims to investigate metabolites of 2-fluoro-deschloroketamine (2F-DCK), a new arylcyclohexylamine derivatives (a group of dissociative ketamine-based substances) using two in vitro experimental approaches, and to compare obtained results by means of molecular networking. Metabolites of 2F-DCK were investigated using both human liver microsomes (HLMs) and hepatic (HepaRG) cell...

DOI: 10.1002/dta.3162 Full text 2f-dck Heparg cell line Metabolism Molecular networking +1

Fatal intoxication related to two new arylcyclohexylamine derivatives (2F-DCK and 3-MeO-PCE).

Forensic Science International July 1, 2021 Thomas Gicquel, Camille Richeval, Vadim Mesli et al. 45 citations

Continuous development and rapid turnover of drug market of new psychoactive substances (NPS) make it difficult to obtain up-to-date analytical methods for efficient detection of intoxication cases with new substances: no analytical data and no previously published concentration values in biological samples are indeed available. In this context, we aim to report the first fatal case involving...

DOI: 10.1016/j.forsciint.2021.110852 Full text 2f-dck 3-meo-pce Arylcyclohexylamine derivatives Forensic +3

LSD Detection and Interpretation in Hair

Current Pharmaceutical Design January 30, 2018 Camille Richeval, Delphine Allorge, Xavier Vanhoye et al. 6 citations

Lysergic acid diethylamide (LSD) is a powerful hallucinogen, active at very low dosages, with, as a direct consequence, potential difficulties to be detected and quantified in a clinical or forensic context, in body fluids and even more in hair. The aim of this work is to review literature data related to hair analysis of LSD with a particular focus on the main issues encountered in LSD...

DOI: 10.2174/1381612823666170622102943 Lysergic acid diethylamide Pubic hair Hair analysis Hallucinogen +8

Prevalence of new psychoactive substances and prescription drugs in the Belgian driving under the influence of drugs population

Drug Testing and Analysis June 22, 2017 Sarah M.r. Wille, Camille Richeval, M. Nachon‐phanithavong et al. 68 citations

Driving under the influence of drugs (DUID) is a worldwide problem. Several countries have adopted DUID legislations which prove their deterrent effect and impact on road safety. However, the use of new psychoactive substances (NPS) and prescription drugs is not known, as the applied roadside screening tests have not yet been adapted for these compounds. In this study, 558 blood samples...

DOI: 10.1002/dta.2232 Pharmacology Psychoactive drug Population Mephedrone +5

In vitro characterization of potential CYP- and UGT-derived metabolites of the psychoactive drug 25B-NBOMe using LC-high resolution MS.

Drug Testing and Analysis February 1, 2016 Yacine Boumrah, Luc Humbert, Mélodie Phanithavong et al.

One of the main challenges posed by the emergence of new psychoactive substances is their identification in human biological samples. Trying to detect the parent drug could lead to false‐negative results when the delay between consumption and sampling has been too long. The identification of their metabolites could then improve their detection window in biological matrices. Oxidative metabolism...

DOI: 10.1002/dta.1865