Bridging ancient substances and modern psychiatry: the role of classic psychedelics in depression treatment.
Neuroscience January 22, 2026 Guilherme Lodetti, Gislaine Zilli Réus, Eduardo Pacheco Rico
Pharmacotherapy for MDD is commonly prescribed to patients, yet fewer than half achieve remission. Moreover, many patients exhibit intolerant responses to pharmacological treatment, highlighting the need to explore new forms of therapy. The present work provides a narrative review of classic psychedelics as an alternative to MDD treatment. In addition, mechanisms by which psychedelics exert...