Abstract This study aimed to evaluate the impact of chronic social isolation on the behavioral profile of male and female Wistar rats within a ketamine (Ket)-induced model of schizophrenia. A total of 144 adult Wistar rats (male and female) were divided into four experimental groups per sex: (1) Socialized + Saline (Sal) (Control group); (2) Socialized + Ket; (3) Isolated + Sal (Isolated...
Pharmacotherapy for depression is commonly prescribed, yet fewer than half of patients achieve remission with a single treatment. Many also experience intolerable side effects, highlighting the need for new treatment approaches. Classic psychedelics interact with the serotonin (5-HT) receptor class and are therefore strongly involved in the treatment of psychiatric illnesses such as depression,...
BackgroundAlcohol use disorder (AUD) remains difficult to treat with lasting success, leading to growing interest in alternative therapeutic approaches. Psychedelic compounds such as Ayahuasca, a traditional brew used in Indigenous Amazonian ceremonies containing N,N-dimethyltryptamine (DMT) along with monoamine oxidase-inhibiting β-carbolines, have shown promise in reducing addictive...