SAR of Psilocybin Analogues: Discovery of a Selective 5‐HT2C Agonist.
ChemInform December 13, 2005 Howard Sard, Govindaraj Kumaran, Cynthia Morency et al.
Abstract For Abstract see ChemInform Abstract in Full Text.
Beth Ann Toth
3 papers in the library · 290 citations · publishing 2004-2005
Papers
SAR of psilocybin analogs: Discovery of a selective 5-HT2C agonist
Bioorganic & Medicinal Chemistry Letters August 3, 2005 Howard Sard, Govindaraj Kumaran, Cynthia Morency et al. 78 citations
An SAR study of psilocybin and psilocin derivatives reveals that 1-methylpsilocin is a selective agonist at the h5-HT(2C) receptor. The corresponding phosphate derivative, 1-methylpsilocybin, shows efficacy in an animal model for obsessive-compulsive disorder, as does 4-fluoro-N,N-dimethyltryptamine. These results suggest a new area for development of novel 5-HT(2C) agonists with applications...
Salvinorin A, an active component of the hallucinogenic sage salvia divinorum is a highly efficacious kappa-opioid receptor agonist: structural and functional considerations.
The Journal of pharmacology and experimental therapeutics March 1, 2004 Charles Chavkin, Sumit Sud, Wenzhen Jin et al. 212 citations
The diterpene salvinorin A from Salvia divinorum has recently been reported to be a high-affinity and selective kappa-opioid receptor agonist (Roth et al., 2002). Salvinorin A and selected derivatives were found to be potent and efficacious agonists in several measures of agonist activity using cloned human kappa-opioid receptors expressed in human embryonic kidney-293 cells. Thus, salvinorin...