Cellular rules underlying psychedelic control of prefrontal pyramidal neurons
bioRxiv (Cold Spring Harbor Laboratory) October 23, 2023 Tyler G. Ekins, Isla A. W. Brooks, Sameer Kailasa et al. 17 citations preprint
ABSTRACT Classical psychedelic drugs are thought to increase excitability of pyramidal cells in prefrontal cortex via activation of serotonin 2 A receptors (5-HT2 A Rs). Here, we instead find that multiple classes of psychedelics dose-dependently suppress intrinsic excitability of pyramidal neurons, and that extracellular delivery of psychedelics decreases excitability significantly more than...