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George K. Aghajanian

Yale University

26 papers in the library · 6,733 citations · publishing 1964-2015

Papers

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Persistence of lysergic acid diethylamide in the plasma of human subjects

Clinical Pharmacology & Therapeutics September 1, 1964 George K. Aghajanian, O. Bing 118 citations

Two micrograms per kilogram of LSD‐25 was administered intravenously to five normal human subjects. The concentration of drug in plasma was determined serially over the subsequent 8 hours. LSD‐25 was found to be present in human plasma in relatively large quantities during the period of peak effect. The half‐life of LSD‐25 in human plasma was calculated to be 175 minutes.

DOI: 10.1002/cpt196455611 (opens in new tab) Lysergic acid diethylamide Human plasma Persistence discontinuity Plasma levels +5