CNS Neurosci Ther
May 1, 2026
Xuewei Qin, Xuanling Chen, Lan Yao et al.
BACKGROUND: Disorders of consciousness (DoC) present significant therapeutic challenges with limited effective interventions. The choice of anesthetic agent during procedures such as spinal cord stimulation may influence long-term neurological outcomes, yet comparative evidence is scarce. This prospective, non-randomized, comparative effectiveness trial investigated the neurophysiological and...
Biochemistry and Cell Biology
2025
Farzaneh Norouzkhani, Esmaeel Ghasemi Gojani, Bo Wang et al.
1 citation
Cellular aging, driven by oxidative stress, mitochondrial dysfunction, and inflammation, is exacerbated by a high-glucose and high-lipid (HGHL) diet, leading to collagen degradation and skin aging. Psilocybin, a naturally occurring compound, has shown potential in reducing symptoms of aging. This study explores the protective effects of psilocybin on BJ-5ta fibroblasts exposed to HGHL, focusing...
Genes
January 29, 2024
Esmaeel Ghasemi Gojani, Bo Wang, Olga Kovalchuk et al.
11 citations
Serotonin emerges as a pivotal factor influencing the growth and functionality of β-cells. Psilocybin, a natural compound derived from mushrooms of the Psilocybe genus, exerts agonistic effects on the serotonin 5-HT2A and 5-HT2B receptors, thereby mimicking serotonin’s behavior. This study investigates the potential impacts of psilocybin on β-cell viability, dedifferentiation, and function...
Psychoactives
January 28, 2024
Esmaeel Ghasemi Gojani, Bo Wang, Dongping Li et al.
12 citations
Psilocybin, an innate compound produced by mushrooms belonging to the Psilocybe genus, is primarily known for its agonistic effects on the serotonin 5-HT2A receptor. This receptor’s functioning is involved in many neurological processes. In the context of this research, our primary aim was to comprehensively investigate the influence of psilocybin as a serotonin receptor agonist on the...
Life
December 15, 2023
Gregory Ian Robinson, Dongping Li, Bo Wang et al.
19 citations
Inflammation plays a pivotal role in the development and progression of inflammatory bowel disease (IBD), by contributing to tissue damage and exacerbating the immune response. The investigation of serotonin receptor 2A (5-HT2A) ligands and transient receptor potential (TRP) channel ligands is of significant interest due to their potential to modulate key inflammatory pathways, mitigate the...
Current Issues in Molecular Biology
August 15, 2023
Gregory Ian Robinson, Dongping Li, Bo Wang et al.
20 citations
Intestinal inflammation and dysbiosis can lead to inflammatory bowel diseases (IBD) and systemic inflammation, affecting multiple organs. Developing novel anti-inflammatory therapeutics is crucial for preventing IBD progression. Serotonin receptor type 2A (5-HT2A) ligands, including psilocybin (Psi), 4-Acetoxy-N,N-dimethyltryptamine (4-AcO-DMT), and ketanserin (Ket), along with transient...
Bo Wang, Tiangang Zhou, Sheng He et al.
preprint
Abstract The default mode network (DMN), a set of transmodal cortical regions, has historically been argued to serve the internal functions of brain. The discovery of this network highlighted the brain’s intrinsic operations. The DMN generally decreases its activity during tasks and increases its activity during relaxed non-task states. It is important to investigate the nature of the DMN in...