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Yeva Zahoruiko

2 papers in the library · 24 citations · publishing 2023-2025

Papers

Anti-Inflammatory Effects of Serotonin Receptor and Transient Receptor Potential Channel Ligands in Human Small Intestinal Epithelial Cells

Current Issues in Molecular Biology August 15, 2023 Gregory Ian Robinson, Dongping Li, Bo Wang et al. 20 citations

Psilocybin (Psi) and eugenol (Eug) together reduced inflammation in human small intestinal epithelial cells. Cells were treated with inflammatory cytokines TNF-α and IFN-γ, then exposed to compounds targeting serotonin 2A receptors (Psi, 4-AcO-DMT, ketanserin) or transient receptor potential channels (capsaicin, curcumin, eugenol). Alone, Psi (40 μM), curcumin (0.5 μM), and eug (50 μM) lowered COX-2 protein without killing cells. The Psi–curcumin combination synergistically cut COX-2 by 28-fold but reduced IL-6 only 1.6-fold. The Psi–eug combination produced the best results: COX-2 dropped 19-fold and IL-6 dropped 10-fold, with no toxicity at any dose. This is the first work to examine psilocybin and 4-AcO-DMT's anti-inflammatory effects in intestinal cells.

DOI: 10.3390/cimb45080427 (opens in new tab) Serotonin 5-HT Receptor Transient computer programming Cell biology +3

LPS-Induced Liver Inflammation Is Inhibited by Psilocybin and Eugenol in Mice

Pharmaceuticals March 23, 2025 Gregory Ian Robinson, Marta Gerasymchuk, Timur Zanikov et al. 4 citations

Psilocybin and eugenol, both individually and combined, reduced inflammation in a mouse model of liver injury induced by lipopolysaccharides. Post-treatment administration produced stronger anti-inflammatory effects than pre-treatment. Psilocybin alone showed the most pronounced reduction of pro-inflammatory cytokines IL-1β, IL-6, and MCP-1, while the combination with eugenol (1:50 ratio) also strongly reduced COX-2 and TNF-α. Histological analysis indicated improved nuclear circularity and less inflammatory infiltration. Eugenol alone increased MCP-1 and GM-CSF, an adverse effect that was mitigated by co-administration with psilocybin. The findings suggest psilocybin and its combination with eugenol as potential therapies for hepatic inflammation.

DOI: 10.3390/ph18040451 (opens in new tab) Psilocybin Eugenol Inflammation Pharmacology +2