Pharmaceuticals
March 23, 2025
Gregory Ian Robinson, Marta Gerasymchuk, Timur Zanikov et al.
4 citations
Background/Objectives: Liver inflammatory diseases are a major global health burden and are often exacerbated by inflammation driven by lipopolysaccharides (LPS) through toll-like receptor 4 signaling. This study evaluates the anti-inflammatory effects of psilocybin and eugenol in an LPS-induced liver inflammation model in C57BL/6J mice. Methods: Mice were treated with psilocybin (0.88 mg/kg)...
Biochemistry and Cell Biology
2025
Farzaneh Norouzkhani, Esmaeel Ghasemi Gojani, Bo Wang et al.
1 citation
Cellular aging, driven by oxidative stress, mitochondrial dysfunction, and inflammation, is exacerbated by a high-glucose and high-lipid (HGHL) diet, leading to collagen degradation and skin aging. Psilocybin, a naturally occurring compound, has shown potential in reducing symptoms of aging. This study explores the protective effects of psilocybin on BJ-5ta fibroblasts exposed to HGHL, focusing...
Biocatalysis and Agricultural Biotechnology
January 25, 2024
Timur Zanikov, Marta Gerasymchuk, Gregory Ian Robinson et al.
10 citations
Neuroinflammation has emerged as a central pathology common to several acute and chronic brain diseases. Recent studies have displayed the anti-inflammatory properties of naturally occurring compounds derived from mushrooms and plants could potentially reduce neuroinflammation and disease progression. In this study, we aimed to investigate the impact of psilocybin and eugenol, as well as their...
Molecules
March 14, 2023
Timur Zanikov, Marta Gerasymchuk, Gregory Ian Robinson et al.
48 citations
Inflammation is an organism’s biological defense mechanism. Acute and chronic inflammation of the body triggers the production of pro- and anti-inflammatory pathways that can affect the content of cytokines in the brain and thus cause brain inflammation. Disorders such as depression and posttraumatic stress disorder (PTSD) are often associated with elevated inflammation. Recently, positive and...