L Taylor Flynn - The Consciousness Library

Sex differences in the acute effects of oral THC: a randomized, placebo-controlled, crossover human laboratory study.

Psychopharmacology October 1, 2024 Ardavan Mohammad Aghaei, Lia Urban Spillane, Brian Pittman et al. 9 citations

Recent reports have shown increased cannabis use among women, leading to growing concerns about cannabis use disorder (CUD). While there is preclinical evidence suggesting biological sex influences cannabinoid effects, human research remains scant. We investigated sex differences in the acute response to oral tetrahydrocannabinol (THC) in humans. 56 healthy men and women with prior exposure to...

DOI: 10.1007/s00213-024-06625-6 Full text Cannabis Marijuana Cannabinoids Endocannabinoid system +2

Psilocybin pulse regimen reduces cluster headache attack frequency in the blinded extension phase of a randomized controlled trial.

Journal of the Neurological Sciences May 15, 2024 Emmanuelle A. D. Schindler, R Andrew Sewell, Christopher Gottschalk et al. 37 citations

In a recent randomized, double-blind, placebo-controlled study, we observed a nonsignificant reduction of attack frequency in cluster headache after pulse administration of psilocybin (10 mg/70 kg, 3 doses, 5 days apart each). We carried out a blinded extension phase to consider the safety and efficacy of repeating the pulse regimen. Eligible participants returned to receive a psilocybin pulse...

DOI: 10.1016/j.jns.2024.122993 Full text Psilocybin Magic mushrooms Cluster headache Headache disorders +8

Exploratory study of the dose-related safety, tolerability, and efficacy of dimethyltryptamine (DMT) in healthy volunteers and major depressive disorder.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology September 1, 2022 Deepak Cyril D'Souza, Shariful A. Syed, L Taylor Flynn et al. 156 citations

There is considerable interest in the therapeutic potential of psychedelic drugs. Dimethyltryptamine (DMT) is a potent, rapid-onset, and short-acting psychedelic drug that has not yet been independently tested for the treatment of depression. The safety, tolerability, and efficacy of intravenous DMT were investigated in treatment-resistant individuals with major depressive disorder (MDD) and...

DOI: 10.1038/s41386-022-01344-y Full text Psychedelic therapy Treatment-resistant depression Depressive disorder Rapid-onset psychedelic +22

Exploratory Controlled Study of the Migraine-Suppressing Effects of Psilocybin.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2021 Emmanuelle A. D. Schindler, R Andrew Sewell, Christopher Gottschalk et al. 138 citations

While anecdotal evidence suggests that select 5-hydroxytryptamine 2A (5-HT2A) receptor ligands, including psilocybin, may have long-lasting therapeutic effects after limited dosing in headache disorders, controlled investigations are lacking. In an exploratory double-blind, placebo-controlled, cross-over study, adults with migraine received oral placebo and psilocybin (0.143 mg/kg) in 2 test...

DOI: 10.1007/s13311-020-00962-y Full text Psilocybin Single dose Migraine headache Lasting therapeutic effects +8

Papers

Sex differences in the acute effects of oral THC: a randomized, placebo-controlled, crossover human laboratory study.

Psilocybin pulse regimen reduces cluster headache attack frequency in the blinded extension phase of a randomized controlled trial.

Exploratory study of the dose-related safety, tolerability, and efficacy of dimethyltryptamine (DMT) in healthy volunteers and major depressive disorder.

Exploratory Controlled Study of the Migraine-Suppressing Effects of Psilocybin.