Effect of a Chiral 4-Alkyl Substituent in Hallucinogenic Amphetamines
Journal of Medicinal Chemistry September 1, 1995 Robert Oberlender, P. V. Ramachandran, Michael P. Johnson et al. 8 citations
The potency of hallucinogenic amphetamine derivatives of the 1-(2,5-dimethoxy-4-alkylphenyl)-2-aminopropane type drops dramatically when the length of the 4-alkyl substituent exceeds propyl or when the substituent is branched. This investigation was directed toward evaluating changes in behavioral and biochemical pharmacology resulting from introducing chirality into the 4-alkyl group of such...