Introduction: Nitrous oxide (N2O) abuse is a growing international concern, with limited effective intervention strategies. This study investigates the potential of Cryptotanshinone (CTS) and its metabolite tanshinone IIA (TAN IIA) in alleviating N2O-induced conditioned place preference (CPP) behavior and modulating dopamine D1 receptor (D1R) and TrkB pathway Methods: In vivo, a CPP mouse model...
Aberrant neuronal Sigma-1 receptor (Sig-1r)-mediated endoplasmic reticulum (ER)- mitochondria signaling plays a key role in the neuronal cytopathology of Alzheimer's disease (AD). The natural psychedelic N, N-dimethyltryptamine (DMT) is a Sig-1r agonist that may have the anti-AD potential through protecting neuronal ER-mitochondrial interplay. 3×TG-AD transgenic mice were administered with...