Cryptotanshinone and Its Metabolite Ameliorate Rewarding Effect of Nitrous Oxide via Nucleus Accumbens D1 Receptor and TrkB Pathway
Current Neuropharmacology May 22, 2026 Sheng-Nan Liu, Wen-Qi Li, Si-Chang Yang et al.
Introduction: Nitrous oxide (N2O) abuse is a growing international concern, with limited effective intervention strategies. This study investigates the potential of Cryptotanshinone (CTS) and its metabolite tanshinone IIA (TAN IIA) in alleviating N2O-induced conditioned place preference (CPP) behavior and modulating dopamine D1 receptor (D1R) and TrkB pathway Methods: In vivo, a CPP mouse model...