N, N-Dimethyltryptamine, a natural hallucinogen, ameliorates Alzheimer's disease by restoring neuronal Sigma-1 receptor-mediated endoplasmic reticulum-mitochondria crosstalk.
Alzheimer's Research & Therapy May 1, 2024 Dan Cheng, Zhuo-Gui Lei, Kin Chu et al. 41 citations
Aberrant neuronal Sigma-1 receptor (Sig-1r)-mediated endoplasmic reticulum (ER)- mitochondria signaling plays a key role in the neuronal cytopathology of Alzheimer's disease (AD). The natural psychedelic N, N-dimethyltryptamine (DMT) is a Sig-1r agonist that may have the anti-AD potential through protecting neuronal ER-mitochondrial interplay. 3×TG-AD transgenic mice were administered with...
DOI: 10.1186/s13195-024-01462-3 (opens in new tab)
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Alzheimer’s disease
Er-mitochondria crosstalk
N,N-Dimethyltryptamine
Cognitive impairment
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