Lucas Petri Damiani

2 papers in the library · 3 citations · publishing 2025-2026

Papers

Prospective, randomized, controlled trial comparing PROpofol versus KetaMINE in rapid sequence intubation in critically ill patients (PROMINE): protocol paper and statistical analysis plan.

Critical care science January 1, 2025 Raysa Cristina Schmidt, Fernando Godinho Zampieri, Fernando Jose Da Silva Ramos et al. 3 citations

The PROMINE study is a planned randomized trial comparing ketamine and propofol for rapid sequence intubation in critically ill patients. Propofol is commonly used but can worsen low blood pressure, whereas ketamine may be safer due to a more favorable effect on blood pressure. The study will randomly assign 170 critically ill patients needing a breathing tube in the intensive care unit to receive either ketamine or propofol. The main outcome is the occurrence of low blood pressure within the first 10 minutes after drug administration. The results aim to guide which hypnotic agent is safer for these vulnerable patients.

DOI: 10.62675/2965-2774.20250133 Full text Ketamine Intubation Breathing tube insertion Pharmacology +14

Implementation and effectiveness of Mindfulness-Based Cognitive Therapy for mild depression in primary care: Protocol for a stepped-wedge cluster RCT

SSM - Mental Health June 16, 2026 Caroline Krauser, Eduardo Jardim Simões, Chester Schmaltz et al.

Depression and anxiety symptoms are a major cause of disability worldwide. Mindfulness-based interventions are proven treatments for mild-to-moderate cases, but evidence on their real-world feasibility and effectiveness is limited, especially in low- and middle-income countries. This paper describes a randomized stepped-wedge trial with qualitative analysis that will evaluate the implementation and effectiveness of Mindfulness-Based Cognitive Therapy for depression symptoms in primary care patients in Brazil. The study aims to generate context-sensitive evidence to improve public health strategies and inform sustainable depression treatments in low- and middle-income countries.

DOI: 10.1016/j.ssmmh.2026.100608 Full text Mindfulness Depression Primary health care Implementation science