Ketamine disrupts consciousness in healthy participants in relation with psychotic-like symptoms.
bioRxiv : the preprint server for biology November 8, 2025 Lucie Berkovitch, Alexandre Salvador, Thomas Andrillon et al. preprint
Ketamine is an NMDA-receptor antagonist, which alters the state of wakeful consciousness at high doses. At lower doses, it induces reversible psychotic-like symptoms and has been used as a pharmacological model of psychosis. In this study, we explore whether low doses of ketamine disrupt conscious access in relation with its psychotomimetic effects, and investigate the neural correlates of its...