Confidence and psychosis: a neuro-computational account of contingency learning disruption by NMDA blockade.
Molecular Psychiatry June 9, 2015 Fabien Vinckier, Raphaël Gaillard, S Palminteri et al.
A state of pathological uncertainty about environmental regularities might represent a key step in the pathway to psychotic illness. Early psychosis can be investigated in healthy volunteers under ketamine, an NMDA receptor antagonist. Here, we explored the effects of ketamine on contingency learning using a placebo-controlled, double-blind, crossover design. During functional magnetic...
DOI: 10.1038/mp.2015.73 (opens in new tab)
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Ketamine
Humans
Psychoses, substance-induced
Receptors, n-methyl-d-aspartate
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