The trace amine-associated receptor 1 (TAAR1) plays a key role in the signaling of the hallucinogen LSD and several antipsychotic drugs. This work presents the molecular structures of the TAAR1-Gs protein complex bound to LSD and to the partial agonist RO5263397, a drug candidate for schizophrenia and addiction. Through mutagenesis, functional studies, and molecular dynamics simulations, the authors describe a versatile binding pocket in TAAR1 that adapts to recognize different ligands, including in the ligand-free state. These results clarify cross-species recognition and partial activation of TAAR1, providing a structural basis for designing new antipsychotic medications.
Adding online Mindfulness-Based Cognitive Therapy (MBCT) to standard treatment for psoriasis reduced lesion severity, depression, quality-of-life impairment, and itching more than standard treatment alone. 109 patients with psoriasis were randomly assigned to treatment as usual or treatment as usual plus eight weekly online MBCT sessions. At 12 weeks, the MBCT group showed greater improvement on the Psoriasis Area and Severity Index, depression scale, dermatology life quality index, and itching scale. No significant difference was found for anxiety. The findings suggest MBCT may enhance comprehensive psoriasis management.
This thesis examines ethnic differences in the ontological beauty of shamanic music in Korea and China within a postmodern context, analyzing musical object forms and their symbolic contexts. While both traditions are religious, Korean shamanic music developed dramatic aesthetic expression due to dynamic historical and cultural influences including shamanism, Buddhism, and Confucianism. Chinese shamanic music emphasizes direct, non-reflective sensory aesthetic religious expression. Despite these differences, both embody an 'overall beauty' in their aesthetic spirit, reflecting fascination and reverence for natural objects and the interconnectedness and balance of all things in nature's cyclical processes.