Negative affective bias in depression following treatment with psilocybin or escitalopram – a secondary analysis from a randomized trial
Translational Psychiatry November 13, 2025 Bruna Giribaldi Cunha, David Nutt, Marieke Martens et al.
Abstract Recent clinical trial data suggests that ratings on depression scales are lowered after psilocybin therapy compared to placebo, though it is unclear what neuropsychological mechanisms underpin these effects. This study compared psilocybin, with an established antidepressant, escitalopram, to investigate whether there are shared or distinct effects on emotional information processing....
DOI: 10.1038/s41398-025-03693-w (opens in new tab)
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Psilocybin
Major depressive disorder
Escitalopram
Depression economics
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